Mavacamten Employing this medicine with any of the following medicines is normally not proposed, but could be necessary in some cases. If both of those medicines are prescribed together, your health care provider may alter the dose or how frequently you use just one or each in the medicines.
B: Can be appropriate. Possibly animal reports display no threat but human experiments not offered or animal scientific studies confirmed small risks and human reports carried out and showed no danger.
C: Use with warning if Rewards outweigh risks. Animal experiments present risk and human experiments not offered or neither animal nor human research carried out.
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modafinil will lessen the level or result of fruquintinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration with reasonable CYP3A4 inducers is unavoidable, continue on to administer fruquintinib at proposed dosage.
modafinil will lessen the extent or impact of pacritinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
etravirine will decrease the level or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
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apalutamide will reduce the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicines that are CYP3A4 substrates may result in reduce exposure to these remedies.
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Cardiovascular disease: In clients with preexisting cardiovascular circumstances, take into account amplified monitoring. Modafinil just isn't encouraged in more information people with documented left-ventricular hypertrophy or even a heritage of your prior cardiotoxicity connected with psychostimulant use.
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When modafinil is employed as being a cognitive enhancer or "good drug" amid wholesome people today in search of improved concentration and productivity,[fourteen][15] its use outside the house health-related supervision raises concerns pertaining to possible misuse or abuse.